Welcome! HADDOCK (High Ambiguity Driven protein-protein DOCKing) is an information-driven flexible docking approach for the modeling of biomolecular complexes.
HADDOCK distinguishes itself from ab-initio docking methods in the fact that it encodes information from identified or predicted protein interfaces in ambiguous interaction restraints (AIRs) to drive the docking process. It also allows to define specific unambiguous distance restraints (e.g. from MS cross-links) and supports a variety of other experimental data including NMR residual dipolar couplings, pseudo contact shifts and cryo-EM maps.
HADDOCK can deal with a large class of modeling problems including protein-protein, protein-nucleic acids and protein-ligand complexes, including multi-bodies (N>2) assemblies.
HADDOCK is one of the flagship software in the EU H2020 BioExcel Center of Excellence for Biomolecular Research.
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HADDOCK is used for excellent science and so far it has been cited more than 5000 times!
Looking for support or questions about HADDOCK’s usage? Check our BioExcel forum!
If HADDOCK is useful for your work, please don't forget to cite us:
G.C.P van Zundert, J.P.G.L.M. Rodrigues, M. Trellet, C. Schmitz, P.L. Kastritis, E. Karaca, A.S.J. Melquiond, M. van Dijk, S.J. de Vries and A.M.J.J. Bonvin (2016).
"The HADDOCK2.2 webserver: User-friendly integrative modeling of biomolecular complexes."
J. Mol. Biol., 428, 720-725 (2015).